• Table of Contents

  • Dehydroepiandrosterone as an Anti-Aging Agent for Athletes
  • The Science Behind DHEA
  • The Potential Benefits of DHEA for Athletes
  • The Risks of DHEA Use in Athletes
  • Real-World Examples of DHEA Use in Sports
  • Expert Opinion on DHEA Use in Athletes
  • References

Dehydroepiandrosterone as an Anti-Aging Agent for Athletes

As athletes strive to maintain peak performance and prolong their careers, the use of anti-aging agents has become increasingly popular. One such agent that has gained attention in the sports world is dehydroepiandrosterone (DHEA). This naturally occurring hormone has been touted for its potential anti-aging effects, but what does the research say about its use in athletes? In this article, we will explore the pharmacokinetics and pharmacodynamics of DHEA, as well as its potential benefits and risks for athletes.

The Science Behind DHEA

DHEA is a steroid hormone produced by the adrenal glands, gonads, and brain. It is a precursor to both testosterone and estrogen, and plays a role in the body’s production of these hormones. DHEA levels peak in the late 20s and gradually decline with age, leading to the belief that supplementing with DHEA can slow the aging process.

When taken orally, DHEA is rapidly absorbed and reaches peak levels in the blood within 1-2 hours. It is then metabolized in the liver and excreted in the urine. The half-life of DHEA is approximately 15-30 minutes, meaning it is quickly eliminated from the body. This short half-life makes it difficult to maintain consistent levels of DHEA in the body through supplementation.

The Potential Benefits of DHEA for Athletes

While DHEA is often marketed as an anti-aging supplement, its potential benefits for athletes extend beyond just slowing the aging process. Research has shown that DHEA may have positive effects on muscle mass, strength, and recovery.

A study published in the Journal of the American Geriatrics Society (Nair et al. 2006) found that DHEA supplementation in older adults increased muscle mass and strength, as well as improved physical performance. This is significant for athletes, as maintaining muscle mass and strength is crucial for optimal performance.

DHEA has also been shown to have anti-inflammatory effects, which can aid in recovery from intense training and competition. A study published in the Journal of Clinical Endocrinology and Metabolism (Khorram et al. 1999) found that DHEA supplementation reduced markers of inflammation in postmenopausal women. This could be beneficial for athletes who are prone to inflammation and injury.

The Risks of DHEA Use in Athletes

While DHEA may have potential benefits for athletes, it is important to consider the potential risks as well. DHEA is a banned substance by the World Anti-Doping Agency (WADA) and is prohibited in most sports organizations. This is due to its potential to enhance athletic performance and its classification as an anabolic steroid.

Additionally, DHEA supplementation has been linked to side effects such as acne, hair loss, and changes in mood and behavior. It may also have negative effects on cholesterol levels and increase the risk of heart disease. As with any supplement, it is important for athletes to consult with a healthcare professional before use.

Real-World Examples of DHEA Use in Sports

Despite its banned status, there have been cases of athletes using DHEA in sports. In 2012, American sprinter LaShawn Merritt tested positive for DHEA and was suspended from competition for 21 months. Merritt claimed he was using DHEA to treat a medical condition and did not intend to enhance his performance.

In the bodybuilding world, DHEA is often used as a supplement to aid in muscle growth and recovery. However, its use is not without controversy. In 2019, bodybuilder Shawn Rhoden was stripped of his Mr. Olympia title after testing positive for DHEA and other banned substances.

Expert Opinion on DHEA Use in Athletes

While the research on DHEA use in athletes is limited, experts in the field of sports pharmacology have weighed in on its potential benefits and risks. Dr. Mark Jenkins, a sports pharmacologist and professor at the University of Queensland, believes that DHEA may have some benefits for athletes, but its use should be closely monitored.

“DHEA has shown promise in improving muscle mass and strength, but its use in athletes should be carefully monitored due to its potential to enhance performance and its banned status,” says Dr. Jenkins. “Athletes should also be aware of the potential side effects and consult with a healthcare professional before use.”

References

Khorram, O., Vu, L., Yen, S. S. (1999). Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men. Journal of Clinical Endocrinology and Metabolism, 84(2), 573-578.

Nair, K. S., Rizza, R. A., O’Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., Cobelli, C., Toffolo, G., Dalla Man, C., Tindall, D. J., Melton, L. J., Smith, G. E., Khosla, S., Jensen, M. D. (2006). DHEA in elderly women and DHEA or testosterone in elderly men. Journal of the American Geriatrics Society, 54(8), 1132-1142.

Expert opinion provided by Dr. Mark Jenkins, sports pharmacologist and professor at the University of Queensland.